Recently several reports have described the usefullness of meperidine as a sole agent for spinal anesthesia. In this study, 50mg meperidine mixed with 15~25mg lidocaine(group 1, n=11), 25mg meperidine mixed with 40~50mg lidocaine(group 2, n=10)
and
65~75mg lidocaine only (group 3, n=9) were respectively injected into the subarachnoid space for elective cesarean section.
@ES The results were as follows:
@EN 1) Hypotension over 20% decrease in systolic blood pressure was found in 7 out of 11 cases in group 1, 5 out of 10 cases in group 2 and 5 out of 9 cases in group 3. The dosage of ephedrine used for hypotension was not significantly different
amoung
the three groups.
2) The time from subarachnoid injection to Bromage scale 0 of group 1 was 77.3(20.3 minutes which was significantly shorter than 125.0(21.5 minutes of group 3(p<0.05).
3) The duration from the administration of the drug until the developent of severe pain postoperatively was checked as 483.6(157.9 minutes in group 1, 424.0(109.4 minutes in group 2 which were significantly longer than 55.5(25 minutes in group
3(p<0.05).
4) Nausea/vomiting were occured 5/0 out of 11 cases in group 1, 4/1 out of 10 cases but none in group 3.
5) Complaints about pain during the operation occured in 5 out of 9 cases in group 3, but none in group 2 and 3.
6) Thye Apgar score and umbilical cord blood gas analyses were not significantly different amoung the three groups.
The results of this study clearly indicate that combining meperidine with hyperbaric spinal lidocaine for cesarean section is a safe and effective method of improving intraoperative pain felief. Furthermore, it provides adquate prolonged
postoperative
analgesia.
|